Twitter is pretty bad. But, it's the only place with Jon Bois tweets. Here are a couple ways you can make Twitter suck less.

2/2/2021 Update: I came across nitter which is a FOSS proxy to Twitter. Currently, you can only view certain profiles but is perfect for my use-case.

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Remove Homepage Crap

The Twitter "What's Happening" sidebar is dedicated to drama and stuff intended to make you angry. To remove this, you'll need uBlock origin (which is something you should have installed if you want a more suck less internet in general). Once you have it installed, go to the dashboard add the following under the "My filters" tab:
twitter.com##.r-1hycxz.r-zso239.r-aqfbo4.css-1dbjc4n

De-numerate

As Ben Grosser writes:
Visible metrics can make us feel more compulsive, competitive, and anxious. Further—without realizing it, we craft rules for ourselves based on what the numbers say, and these rules affect what we post, who we friend, and which posts we “like.”
He's written a tool to remove all metrics (likes, retweets, replies, followers, etc.) which you can install through one sources linked here. I am personally using Violentmonkey.

Remove Interests

Twitter keeps track of what it think's you're interesting in, then uses it to show you "relevant" tweets (and ads). You can manually prune these here, but the list can get very long, very quick. You can automate "un-interesting" all topics by pasting Ed Johnson-Williams' script in console:
"use strict;"
var labelSelector = ".r-1p0dtai.r-1ei5mc7.r-1pi2tsx.r-1d2f490.r-crgep1.r-orgf3d.r-t60dpp.r-u8s1d.r-zchlnj.r-ipm5af.r-13qz1uu"

// Get all the interests that Twitter has inferred about your account
var interests = Array.from(document.querySelectorAll(labelSelector));
console.log(`${interests.length} total interests found`);
var checkedInterests = 0;
console.log(`Starting…`);

// For each of those interests, if it's selected, uncheck the checkbox 
interests.forEach((interest) => {
    if (interest.checked) {
        checkedInterests++
        interest.click();
        console.log(`${checkedInterests} of ${interests.length}`)
    }
});

console.log(`Finished`);

Remove Sugguested Content

Under the muted keywords section, you paste Jake Bellacera's script to automatically add sugguest content keywords to the blocklist, cleaning up your timeline.
const delayMs = 500; // change this if you feel like its running too fast
const keywords = `ActivityTweet
generic_activity_highlights
generic_activity_momentsbreaking
RankedOrganicTweet
suggest_activity
suggest_activity_feed
suggest_activity_highlights
suggest_activity_tweet
suggest_grouped_tweet_hashtag
suggest_pyle_tweet
suggest_ranked_organic_tweet
suggest_ranked_timeline_tweet
suggest_recap
suggest_recycled_tweet
suggest_recycled_tweet_inline
suggest_sc_tweet
suggest_timeline_tweet
suggest_who_to_follow
suggestactivitytweet
suggestpyletweet
suggestrecycledtweet_inline`.split(/\W+/);

const nativeInputValueSetter = Object.getOwnPropertyDescriptor(window.HTMLInputElement.prototype, "value").set;

const addMutedKeyword = keyword => {
    const input = document.querySelector("[name='keyword']");
    nativeInputValueSetter.call(input, keyword);
    input.dispatchEvent(new Event('input', { bubbles: true }));
    document.querySelector("[data-testid='settingsDetailSave']").click();
}

const delay = () => {
    return new Promise(res => setTimeout(res, delayMs));
};

keywords.reduce(async (prev, keyword) => {
    await prev;
    document.querySelector("a[href='/settings/add_muted_keyword']").click();
    await delay();
    addMutedKeyword(keyword);
    return delay();
}, Promise.resolve());
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In the end, you should get something less distracting and more focused on the content you enjoy. For example, here's my new homepage: End result